Chicken Bubble Biscuit Bake Casserole Recipe
Introduction
Chicken Bubble Biscuit Bake Casserole is a comforting, easy-to-make dish perfect for busy weeknights. Tender chicken, creamy sauce, mixed vegetables, and fluffy biscuit pieces combine for a hearty and satisfying meal everyone will love.

Ingredients
- 2 cups cooked chicken, shredded or diced (rotisserie works great)
- 1 (10.5 oz) can cream of chicken soup (or cream of mushroom)
- 1/2 cup sour cream or plain Greek yogurt
- 1/2 cup milk
- 1 cup frozen mixed vegetables (peas, carrots, corn, beans)
- 1 tsp garlic powder
- 1/2 tsp onion powder
- Salt & pepper to taste
- 1 (16 oz) can refrigerated biscuit dough, cut into quarters
- 1 cup shredded cheddar cheese or mozzarella
- 1 tbsp melted butter, optional, for brushing
Instructions
- Step 1: Preheat your oven to 350°F (175°C) and lightly grease a 9×13-inch baking dish.
- Step 2: In a large bowl, combine the cooked chicken, cream of chicken soup, sour cream, milk, frozen mixed vegetables, garlic powder, onion powder, salt, and pepper. Stir until the mixture is smooth and well blended.
- Step 3: Fold the quartered biscuit dough pieces into the chicken mixture, coating them evenly.
- Step 4: Pour the entire mixture into the prepared baking dish, spreading it out evenly. Sprinkle the shredded cheese over the top in an even layer.
- Step 5: Cover the baking dish with foil and bake for 20 minutes. Then remove the foil and bake for an additional 10 to 15 minutes, until the biscuits are puffed, golden, and fully cooked through.
- Step 6: If desired, brush the top of the casserole with melted butter for extra flavor and richness. Let the casserole cool for a few minutes before serving.
Tips & Variations
- Swap cream of chicken soup with cream of mushroom or cream of celery for a different flavor base.
- Add cooked bacon or diced ham for extra protein and smoky flavor.
- Use fresh vegetables like chopped broccoli or bell peppers instead of frozen for added texture.
- For a lighter version, substitute sour cream with plain Greek yogurt and use low-fat cheese.
- Brush biscuits with melted butter and sprinkle with herbs like thyme or parsley before baking for enhanced aroma.
Storage
Store any leftover casserole covered in the refrigerator for up to 3 days. To reheat, warm in the oven at 350°F (175°C) until heated through, about 15-20 minutes, to keep the biscuits from getting soggy. You can also microwave individual portions, but the biscuit topping may soften.
How to Serve

Serve this delicious recipe with your favorite sides.
FAQs
Can I use homemade biscuit dough instead of canned?
Yes, homemade biscuit dough works well. Just cut the dough into similar-sized pieces and fold them into the mixture as directed.
Is it possible to make this casserole ahead of time?
Absolutely. Assemble the casserole, cover it tightly, and refrigerate overnight. Bake it the next day, adding a few extra minutes to the baking time if needed.
PrintChicken Bubble Biscuit Bake Casserole Recipe
This Chicken Bubble Biscuit Bake Casserole is a comforting, hearty dish featuring tender shredded chicken mixed with creamy soup, veggies, and seasonings, all wrapped in flaky biscuit dough and topped with melted cheese. Perfect for an easy weeknight meal, it combines creamy, savory flavors with a satisfying biscuit topping that bakes golden and fluffy.
- Prep Time: 15 minutes
- Cook Time: 35 minutes
- Total Time: 50 minutes
- Yield: 6 servings 1x
- Category: Casserole
- Method: Baking
- Cuisine: American
- Diet: Low Fat
Ingredients
Chicken Filling
- 2 cups cooked chicken, shredded or diced (rotisserie works great)
- 1 10.5 oz can cream of chicken soup (or cream of mushroom)
- 1/2 cup sour cream or plain Greek yogurt
- 1/2 cup milk
- 1 cup frozen mixed vegetables (peas, carrots, corn, beans)
- 1 tsp garlic powder
- 1/2 tsp onion powder
- Salt & pepper to taste
Biscuit Topping
- 1 16 oz can refrigerated biscuit dough, cut into quarters
- 1 cup shredded cheddar cheese or mozzarella
- 1 tbsp melted butter (optional, for brushing)
Instructions
- Preheat and Prepare: Preheat your oven to 350°F (175°C). Lightly grease a 9×13-inch baking dish to prevent sticking and ensure even cooking.
- Mix the Filling: In a large bowl, combine the cooked shredded chicken, cream of chicken soup, sour cream, milk, frozen mixed vegetables, garlic powder, onion powder, salt, and pepper. Stir the mixture thoroughly until all ingredients are evenly incorporated and smooth.
- Add Biscuits: Fold the quartered biscuit dough pieces gently into the chicken mixture, ensuring each biscuit piece is coated with the creamy filling.
- Assemble the Casserole: Pour the combined mixture into the prepared baking dish in an even layer. Sprinkle the shredded cheddar or mozzarella cheese evenly over the top to create a flavorful cheesy crust.
- Bake Covered: Cover the baking dish with foil and bake in the preheated oven for 20 minutes. This allows the filling to heat through and the biscuits to start cooking.
- Bake Uncovered: Remove the foil and continue baking for an additional 10 to 15 minutes. Bake until the biscuits are puffed, golden brown, and fully cooked through, and the cheese on top is melted and bubbly.
- Finish and Serve: If desired, brush the top of the biscuits with melted butter for extra flavor and a glossy finish. Let the casserole cool slightly before serving to allow it to set for easier portioning.
Notes
- You can substitute cream of chicken soup with cream of mushroom for a different flavor.
- Sour cream can be replaced with plain Greek yogurt as a healthier alternative.
- Use any shredded cheese you prefer; mozzarella keeps it mild while cheddar adds more sharpness.
- Leftover cooked chicken from any recipe works perfectly for this casserole.
- To make it gluten-free, use gluten-free biscuit dough and ensure the soup is gluten-free.
- For added texture, sprinkle breadcrumbs or crushed crackers on top before baking uncovered.
Keywords: chicken casserole, biscuit bake, creamy chicken bake, easy dinner, comfort food, baked chicken dish, chicken and biscuits

